Viktor Krchnak, Research Professor
Biography
Viktor Krchňák studied chemistry at the Faculty of Natural Sciences of the Masaryk University in Brno, Czechoslovakia. He earned his PhD in organic chemistry from the Institute of Organic Chemistry and Biochemistry of the Czechoslovak Academy of Sciences in Prague, under the supervision of Prof. Zdenek Arnold. After holding several industrial positions with small biotech companies in the US, he joined the faculty of the University of Notre Dame as a research professor in May 2003.
Research Interests
Research interest covers combinatorial chemistry in general and solid phase chemistry in particular. His group introduced novel coding technique for the synthesis on modular solid support (lantern necklace coding), new concept for the solid phase synthesis of traceless heterocyclic libraries, cleavage of resin-bound compounds by gaseous reagents, the “split-split” method for the synthesis of sizable combinatorial libraries (up to 60,000 compounds), instrumentation and logistics for high throughput organic synthesis. Numerous his inventions resulted in commercially available personal chemistry tools (www.torviq.com).
Recent Papers
M. Soural, I. Bouillon, and V. Krchnak. Combinatorial Libraries of Bis-heterocyclic Compounds with Skeletal Diversity. J.Comb.Chem. 10:923-933, 2008.
I. Bouillon, M. Soural, and V. Krchnak. Resin Capsules: Permeable Containers for Parallel/Combinatorial Solid-Phase Organic Synthesis. J.Comb.Chem. 10:714-720, 2008.
I. Bouillon, J. Zajicek, N. Pudelova, and V. Krchnak. Remarkably Efficient Synthesis of 2H-Indazole 1-Oxides and 2-H-Indazoles via Tandem Carbon-Carbon Followed by Nitrogen-Nitrogen Bonds Formation. J.Org.Chem. 73:9027-9032, 2008.
M. Soural and V. Krchnak. Efficient Solid-Phase Synthesis of 2-Substituted-3-Hydroxy-4(1H)-Quinolinone-7-Carboxamides with Two Diversity Positions. J.Comb.Chem. 9:793-796, 2007.
V. Krchnak, K. R. Waring, B. Noll, U. Moellmann, H.-M. Dahse, and M. J. Miller. Evolution of Natural Product Scaffolds by Acyl- and Arylnitroso Hetero Diels-Alder Reactions: New Chemistry on Piperine. J.Org.Chem. 73:4559-4567, 2008.
N. Pudelova and V. Krchnak. Multiplicity of Diverse Heterocycles from Polymer-Supported α-Acylamino Ketones. J.Comb.Chem. 11:in press, 2009.
Contact Information
- Research Professor
- Office: 345 Nieuwland
- Phone: 574.631.5113
- Contact by Email
- Group Website
