Robert Stahelin

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Biography

Professor Stahelin received his B.S. in biochemistry from the University of Illinois-Chicago in 1998. He earned his Ph.D. in chemistry from the University of Illinois-Chicago in 2003 for studying the structural basis of lipid-protein interactions in health and disease. During postdoctoral work at the University of Illinois-Chicago he investigated the mechanisms with which bioactive lipid signals recruit peripheral proteins in cell signaling and membrane trafficking. He joined the Notre Dame and Indiana University School of Medicine-South Bend faculty in July of 2006.

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Research Interests

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Recent Papers

Subramanian, P., Vora, M., Gentile, L.B., Stahelin, R.V., and Chalfant, C.E. “Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms” (2007) J. Lipid Res., 48, 2701-2708.
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Stahelin, R.V., Karathanassis, D., Murray, D., Perisic, O., Bruzik, K.S., Williams, R.L., and Cho, W. “Structural and Membrane Binding Analysis of the PX domain of Bem1p” (2007) J. Biol. Chem., 282, 25737-25747. Link
Hom, R., Vora, M., Regner, M., Subach, O.M., Cho, W., Verkhusha, V.V., Stahelin, R.V., and Kutateladze, T.G. “pH-Dependent Binding of the ENTH Domain of Epsin and the ANTH Domain of AP180 to PI(4,5)P2-Containing Bilayers (2007) J. Mol. Biol., 373, 412-423.
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Stahelin, R.V., Subramanian, P., Vora, M., Cho, W., and Chalfant, C.E. “Ceramide-1-Phosphate Binds Group IVA Cytosolic Phospholipase A2 Via a Novel Site in the C2 Domain” (2007) J. Biol. Chem., 282, 20467-20474.
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Hanshaw, R.G., Stahelin, R.V., and Smith, B.D. “Noncovalent Keystone Interactions Controlling Biomembrane Structure” (2007) Chemistry, 14, 1690-1697. Link
Cho, W., and Stahelin, R.V. “Membrane-Protein Interactions in Membrane Trafficking and Signal Transduction” (2005) Annu. Rev. Biophys. Biomol. Struct. 34:119-151.
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