Faculty & Research // Department of Chemistry and Biochemistry // University of Notre Dame

Biography

1993 Dr. rer. nat. University of Bonn, Germany (Prof. E. Steckhan)
1993-1995 Postdoctoral Fellow, Dept. of Chemistry, UCLA (Prof. K. N. Houk)
1995 Visiting Assistant Professor, University of Notre Dame
1996-2001 Assistant Professor, University of Notre Dame
1999–present PI, Walther Cancer Research Center
2001–2005 Associate Professor, University of Notre Dame
2005- present Professor, University of Notre Dame

Awards
1997 NIH FIRST Award
1997 NSF Carreer Award
2001 Camille Dreyfus Teacher-Scholar Award
2004 Kaneb Teaching Award

Research Interests

Computational and Physical Organic Chemistry, Computational Drug Design, Biophysical Chemistry, Enzyme Mechanisms, Electron Transfer Induced Reactions, Transition Metal Catalyzed Reactions and Design of Ligands for Enantioselective Catalysis

Recent Papers

D.-F. Wang, O. Wiest, P. Helquist “Zinc Binding in HDAC Inhibitors. A DFT Study” J. Org. Chem. 2007, 72, accepted for publication

K. C. Fortner, D. S. Laitar, J. Muldoon, S. B. Braun-Sand, O. Wiest, L. Pu, S. N. Brown “Ultrafast and Ultraslow Oxygen Atom Transfer Reactions Between Late Metal Centers” J. Am. Chem. Soc. 2007, 129, 588-600

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P. Donoghue; P. Helquist, O. Wiest “Ligand and Substrate Effects on the Mechanism of Rhodium-Catalyzed Hydrogenation of Enamides” J. Org. Chem. 2007 72, 839-847.

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P. Donoghue; O. Wiest, “Structure and Reactivity of Radical Cations: New Twists on Old Concepts” Chemistry- Europ. J. 2006, 12, 7018-7026

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A. P.R. Zabell, A. D. Schroff jr.; R. L. van Etten, O. Wiest, C. V. Stauffacher “Crystal structure of human B-form low molecular weight phosphotyrosyl phosphatase at 1.6 Å resolution” J. Biol. Chem. 2006, 281, 6520-6527.

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L. L. O’Neil, O. Wiest “A Selective, Non-Covalent Assay for Base Flipping in DNA” J. Am. Chem. Soc. 2005, 127, 16800-16801.

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