Bradley D. Smith

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Biography

Professor Smith earned a B. S. degree from the University of Melbourne, and a Ph.D. from the Pennsylvania State University (1988). He conducted postdoctoral research at Oxford University and then at Columbia University before joining the faculty at Notre Dame (1991). In 1994 he was named a Research Corporation Cottrell Scholar. He currently serves on the editorial advisory boards of Supramolecular Chemistry and The Journal of the American Chemical Society and the science advisory committee for the funding agency Research Corporation.

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Research Interests

The research conducted in this bioorganic chemistry laboratory is multidisciplinary and encompasses topics ranging from supramolecular chemistry to in vivo animal imaging. As a result, the students receive broad training and experience in organic synthesis, host-guest chemistry, biophysical and spectroscopic methods, cell culture, and in vivo models of cancer and bacterial infection. The goal in our biomembrane project is to design and synthesize organic molecules that affect the dynamics of biological membranes. Specifically, we are interested in controlling (activating or inhibiting) the biologically and pharmaceutically important processes of cell surface recognition, phospholipid flip-flop, chloride transport, endocytosis, and membrane protein-protein interactions. We are also developing novel fluorescent imaging agents for tumors, apoptotic tissue, and bacterial infection. The Supramolecular Chemistry program designs and evaluates host molecules, transporter molecules, catalysts, and mechanically interlocked molecules. We have recently discovered squaraine-rotaxanes as extremely bright and stable fluorescent Near-IR dyes.

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Recent Papers

New Reagents for Phosphatidylserine Recognition and Detection of Apoptosis. Hanshaw, R. G.; Smith, B. D. Bioorg. Med. Chem. 2005, 13, 5035-5042.
Squaraine-Derived Rotaxanes: Highly Stable Fluorescent Near-IR Dyes. Arunkumar, E.; Fu, N.; Smith, B. D. Chem.-Eur. J. 2006, 12, 4684-4690.
Development of Synthetic Transporters for Anions. Smith, B. D.; Davis, A. P.; Shephard, D. Chem. Soc. Rev., 2007, 36, 348-357.
Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe. Leevy, W. M.; Gammon, S. T.; Hua Jiang, H.; Johnson, J. R.; Maxwell, D. J.; Marquez, M.; Piwnica-Worms, D.; Smith, B. D. J. Am. Chem Soc. 2006, 128, 16476-16477.
For direct link to Smith Group Website Click on:
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flip_flop.jpg sensors.jpg rotaxane.jpg macrocycle.jpg
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